The World Health Organization released a report in 2017 in regards to Cannabidiol and one conclusion reads: “In humans, CBD exhibits no effects indicative of any abuse or dependence potential…. To date, there is no evidence of public health related problems associated with the use of pure CBD.”
That powerful statement penned by the World Health Organization is one of many that praises the potential of CBD to assist with a myriad of health issues in both humans and pets. However, there is an important question we all need to consider, “When should I not take CBD?”
Firstly, always consult with a doctor if you are on medications and interested in taking CBD.
Cytochrome P-450 Enzyme System
The Cytochrome P-450 Enzyme System is found in the liver and the system responsible for metabolizing the majority of any drugs taken. The drugs are broken down by the system and turned into simple substances that our body can use or lose. The system is comprised of over 50 different enzymes to handle the metabolization process. CBD, when taken at higher doses, can affect the metabolization rate of this system in turn shifting how and the rate in which drugs are metabolized. In addition to CBD, grapefruit, St. John’s Wort, Goldenseal and Watercress can also slow the system’s metabolization rate. A slower metabolization rate can result in toxic drugs lingering in our body. An example of lingering toxins: CBD when taken with Nyquil (which contains Doxylamine) results in a slower metabolization of Doxylamine and higher levels of drowsiness and impaired motor function.
More studies are required to determine dosages labeled as “high” and also more information is needed regarding how CBD interacts with the Cytochrome P-450 Enzyme System and metabolization rates. It is best, at this point, to consult a doctor on a case-by-case basis.
Common questions include: When and if it is safe to mix CBD with Tylenol? Can I take CBD and Xanex? Can I take CBD and Gabapentin? Can I take CBD and Benadryl? These are all great questions to be asking if you are taking pharmaceuticals. Consult your doctor or the pharmacist in your local pharmacy if you have concerns.
The Department of Medicine and Clinical Pharmacology has compiled a wonderful list of drugs that are linked (Clickable) to all the known inhibitors and Inducers. It is called the Drug Interactions Flockhart Table. An inducer can increase the metabolism of a drug while an inhibitor can block the metabolism of a drug.
Where to Buy CBD
Once a doctor gives the green light, ingesting CBD offers little to be concerned about just as the World Health Organization has pointed out. Can we reccomend our well loved Balance CBD Oil? The biggest concern you have as a consumer is about the CBD oil you choose to buy. Not all CBD oil is equal in quality. Be certain to read labels, familiarize yourself with CBD related terms and ask for lab tests and more information if you have questions. The CBD company you choose to purchase from should be clear, transparent and responsive. Someone… like us, we love to connect. Ask us questions and let’s discuss the healing benefits of CBD.